abstract：:Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen rep...

journal_title：Neurobiology of aging

authors： Eberling JL,Wu C,Haan MN,Mungas D,Buonocore M,Jagust WJ

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:The goal of this project was to compare MRI measures of hippocampal, entorhinal cortex (ERC), and whole brain longitudinal change in cognitively normal elderly controls (C), non-demented subjects with cognitive impairment (CI), and demented (D) subjects. METHODS:16 C, 6 CI, and 7 D subjects of comparable age w...

journal_title：Neurobiology of aging

authors： Cardenas VA,Du AT,Hardin D,Ezekiel F,Weber P,Jagust WJ,Chui HC,Schuff N,Weiner MW

更新日期：2003-07-01 00:00:00

abstract：:Data are emerging that the altered development of adrenocortical and emotional reactivity in individuals exposed perinatally to adverse events is reflected in cognitive change and that maternal care is an important determinant. However, early trauma does not cause a generalized cognitive decline at older age, but rath...

journal_title：Neurobiology of aging

authors： de Kloet ER,Oitzl MS

更新日期：2003-05-01 00:00:00

abstract：:Early manifestations of brain aging have received much less attention than the drastic degeneration of AD and MID. During nonpathological changes of normal aging, brain systems differ in the involvement of neuron loss. Spatial learning can become impaired without evidence for neuron loss, whereas eye-blink conditionin...

journal_title：Neurobiology of aging

authors： Finch CE

更新日期：2003-05-01 00:00:00

abstract：:The application of beta-amyloid (Abeta) is cytotoxic to endothelial cells, promotes vasoconstriction and impairs nitric oxide (NO) generation or action. However, there is no information on the effect of intracellular Abeta on endothelial cell biology, although recent studies indicate that neuronal Abeta drives Alzheim...

journal_title：Neurobiology of aging

authors： Suhara T,Magrané J,Rosen K,Christensen R,Kim HS,Zheng B,McPhie DL,Walsh K,Querfurth H

更新日期：2003-05-01 00:00:00

abstract：:Several signaling mechanisms that are crucial for the induction of long-term potentiation (LTP) by theta frequency (5 Hz) trains of synaptic stimulation are altered in aged animals. To determine whether theta frequency stimulation-induced LTP is particularly sensitive to changes in synaptic function that occur in aged...

journal_title：Neurobiology of aging

authors： Watabe AM,O'Dell TJ

更新日期：2003-03-01 00:00:00

abstract：:Brain injury increases the risk of Alzheimer's disease (AD) through unknown mechanisms. We studied deposition of amyloid-beta protein (Abeta) in cells exposed to transforming growth factor beta1 (TGFbeta1), a cytokine that regulates cell metabolism during brain injury, and apolipoproteinE (apoE), the major lipid trans...

journal_title：Neurobiology of aging

authors： Mazur-Kolecka B,Frackowiak J,Le Vine H 3rd,Haske T,Evans L,Sukontasup T,Golabek A

更新日期：2003-03-01 00:00:00

abstract：:We studied the hippocampal angle and spatial relationships of medial temporal lobe (MTL) structures, using midbrain colliculi and inter-collicular sulcus (ICS) as landmarks, and measured MTL width on axial 3D-T1-weighted MRI at ICS level in 41 normal, aged participants. Mean hippocampal angle was 29 degrees (range 17-...

journal_title：Neurobiology of aging

authors： Gao FQ,Black SE,Leibovitch FS,Callen DJ,Lobaugh NJ,Szalai JP

更新日期：2003-01-01 00:00:00

abstract：:The present study investigated if a causal relation exists between serum concentrations of precursors and metabolites of cholesterol and cognitive performance in a healthy aging population. Cognitive function addressing four domains of 144 individuals (30-80 years) was tested at baseline and after 6 years of follow-up...

journal_title：Neurobiology of aging

authors： Teunissen CE,De Vente J,von Bergmann K,Bosma H,van Boxtel MP,De Bruijn C,Jolles J,Steinbusch HW,Lütjohann D

更新日期：2003-01-01 00:00:00

abstract：:Extracellular senile plaques (SPs) are hallmark brain lesions of sporadic Alzheimer's disease (AD) and the likely consequence of genetic mutations that cause familial AD by increasing production of amyloidogenic amyloid-beta (Abeta). Although Abeta vaccines and inhibitors of amyloidogenic secretases are potential AD t...

journal_title：Neurobiology of aging

authors： Lee VM

更新日期：2002-11-01 00:00:00

abstract：:The 'amyloid hypothesis' has guided research into Alzheimer's disease (AD) for more than a decade. A detailed review of the relevant data led us to conclude that some data, particularly those from transgenic mice, are inconsistent with the predictions of the amyloid hypothesis. Instead, most data are consistent with t...

journal_title：Neurobiology of aging

authors： Bishop GM,Robinson SR

更新日期：2002-11-01 00:00:00

abstract：:Aging produces a loss in a number of behavioral and cognitive functions, including sleep. Hypocaloric diet is one of the few methods that have been shown to retard the effects due to age. However, the effects of such a diet on sleep have never been investigated. In the present study, 21 months old male F344 rats fed a...

journal_title：Neurobiology of aging

authors： Salin-Pascual RJ,Upadhyay U,Shiromani PJ

更新日期：2002-09-01 00:00:00

abstract：:In Pick disease and progressive supranuclear palsy (PSP), accumulations of phosphorylated tau are associated with oxidative stress, although the mechanism linking these features remains unknown. However, we suspected that the oxidative stress-induced activation of mitogen-activated protein kinases might lead to tau ph...

journal_title：Neurobiology of aging

authors： Hartzler AW,Zhu X,Siedlak SL,Castellani RJ,Avilá J,Perry G,Smith MA

更新日期：2002-09-01 00:00:00

abstract：:Relationships between age-related changes in sleep patterns and neuronal activity have received scant attention. In the present study, reticularis pontis oralis (RPO) and ventral tegmental nucleus of Gudden (VTN) neurons were recorded in unanesthetized restrained young (3 months) and old (23 months) Sprague-Dawley rat...

journal_title：Neurobiology of aging

authors： Bassant MH,Poindessous-Jazat F

更新日期：2002-07-01 00:00:00

abstract：:There is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation that is increased in the ventricular fluid and brains of patients with Alzheimer's disease. We measured the concentrations of h...

journal_title：Neurobiology of aging

authors： Selley ML,Close DR,Stern SE

更新日期：2002-05-01 00:00:00

abstract：:A variety of studies have shown an effect of estrogen on dopamine function and suggest that estrogen may modulate central dopaminergic activity. Positron emission tomography (PET) and the dopamine metabolism tracer, [18F]6-fluoro-L-m-tyrosine (FMT) were used to evaluate dopaminergic function in the frontal cortex and ...

journal_title：Neurobiology of aging

authors： Eberling JL,Roberts JA,Taylor SE,VanBrocklin HF,O'Neil JP,Nordahl TE

更新日期：2002-05-01 00:00:00

abstract：:The activities of presenilin 1 (PS1) and 2 modulate the proteolytic processing of amyloid precursor proteins to produce Abeta1-42, and mutations in these proteins are associated with an accelerated rate of Abeta deposition. PS1 and PS2 themselves are subject to a highly-regulated endoproteolytic cleavage to generate s...

journal_title：Neurobiology of aging

authors： Borchelt DR,Lee MK,Gonzales V,Slunt HH,Ratovitski T,Jenkins NA,Copeland NG,Price DL,Sisodia SS

更新日期：2002-03-01 00:00:00

abstract：:The Parkinson's disease (PD)-related inclusion body pathology comprises Lewy bodies (LBs) as well as Lewy neurites (LNs). The distribution and severity of this pathology were investigated in the thalamus of 12 autopsy cases with clinically diagnosed and neuropathologically confirmed PD. The LBs and LNs were visualized...

journal_title：Neurobiology of aging

authors： Rüb U,Del Tredici K,Schultz C,Ghebremedhin E,de Vos RA,Jansen Steur E,Braak H

更新日期：2002-03-01 00:00:00

abstract：:Lipsitz and Goldberger proposed that there is a loss in the complexity of physiological and behavioral systems with aging and disease. Here, we show that this unidirectional view of the change in system complexity is too narrow in its consideration of the actual changes that occur with aging and disease. An increase o...

journal_title：Neurobiology of aging

authors： Vaillancourt DE,Newell KM

更新日期：2002-01-01 00:00:00

abstract：:In order to investigate inflammation and apoptosis in Creutzfeldt-Jakob disease (CJD) patients, we analyzed astrocytes, microglia and apoptotic neurons in brain and IL-1beta in cerebrospinal fluid (CSF). Our results showed increased numbers of astrocytes in CJD and increased numbers of microglia and apoptotic neurons ...

journal_title：Neurobiology of aging

authors： Van Everbroeck B,Dewulf E,Pals P,Lübke U,Martin JJ,Cras P

更新日期：2002-01-01 00:00:00

abstract：:In Alzheimer's disease (AD) inflammatory processes occur in pathologically vulnerable brain regions. The objective of this study is to compare both the release and the presence of microvessel-associated cytokines in vessels isolated from the brains of AD patients to microvessels from control brains. Microvessels are i...

journal_title：Neurobiology of aging

authors： Grammas P,Ovase R

更新日期：2001-11-01 00:00:00

abstract：:Biochemical, genetic, and epidemiological evidence indicates that inflammation is an essential part of the pathogenesis of Alzheimer's disease. Over the last decade, we and others have focused on the mechanism by which specific inflammatory molecules contribute to the Alzheimer pathogenic pathway. In particular, we ha...

journal_title：Neurobiology of aging

authors： Potter H,Wefes IM,Nilsson LN

更新日期：2001-11-01 00:00:00

abstract：:We measured midbrain structures of 194 subjects without neurological disorders, using T2-weighted MR imaging. Age was negatively correlated with the maximum anteroposterior distance of the midbrain through the substantia nigra (MD), and the average distance from the substantia nigra to the red nucleus (SNRND), while a...

journal_title：Neurobiology of aging

authors： Sohmiya M,Tanaka M,Aihara Y,Hirai S,Okamoto K

更新日期：2001-07-01 00:00:00

abstract：:We recently demonstrated that retinal ganglion cell function, optic nerve head parameters and the retinal nerve fiber layer thickness are not altered in early dementia of the Alzheimer type (DAT). Our current objective was to assess whether the function of cells located more distally in the retina is also unaffected b...

journal_title：Neurobiology of aging

authors： Justino L,Kergoat M,Bergman H,Chertkow H,Robillard A,Kergoat H

更新日期：2001-07-01 00:00:00

abstract：:To investigate possible age-associated changes in human synaptic connectivity, superior-middle frontal cortex (Brodmann area 9) was evaluated with ultrastructural techniques. Short post mortem autopsy tissue was obtained from 37 cognitive normal individuals ranging in age from 20 to 89 years. A minimum of five subject...

journal_title：Neurobiology of aging

authors： Scheff SW,Price DA,Sparks DL

更新日期：2001-05-01 00:00:00

abstract：:Parkinson's disease (PD) and Alzheimer's dementia (AD) are often associated with an autonomic neuropathy. The extent of autonomic involvement, however is poorly defined and unpredictable. In order to assess the autonomic cardiovascular regulation baroreflex sensitivity (BRS) was determined non-invasively in 23 patient...

journal_title：Neurobiology of aging

authors： Szili-Török T,Kálmán J,Paprika D,Dibó G,Rózsa Z,Rudas L

更新日期：2001-05-01 00:00:00

abstract：:Decreased levels of cerebrospinal fluid (CSF) Abeta42 is a diagnostic marker of Alzheimer's disease. To clarify the biological basis of this marker, the physiological alterations of CSF Abeta40 and Abeta42 by aging were studied. CSF samples from 92 normal subjects between 8 and 89 years old were measured using a speci...

journal_title：Neurobiology of aging

authors： Shoji M,Kanai M,Matsubara E,Tomidokoro Y,Shizuka M,Ikeda Y,Ikeda M,Harigaya Y,Okamoto K,Hirai S

更新日期：2001-03-01 00:00:00

abstract：:Chronic hypertension during aging is a serious threat to the cerebral vasculature. The larger brain arteries can react to hypertension with an abnormal wall thickening, a loss of elasticity and a narrowed lumen. However, little is known about the hypertension-induced alterations of cerebral capillaries. The present st...

journal_title：Neurobiology of aging

authors： Farkas E,De Jong GI,Apró E,Keuker JI,Luiten PG

更新日期：2001-03-01 00:00:00

abstract：:Young, middle-aged, old, and senescent Fischer 344 x Brown Norway F1 hybrid rats were trained in either the trace or delay eyeblink conditioning task in order to investigate how aging affects associative learning and memory over the life span. Senescent rats at 34-35 months showed severe impairments in acquisition of ...

journal_title：Neurobiology of aging

authors： Knuttinen MG,Gamelli AE,Weiss C,Power JM,Disterhoft JF

更新日期：2001-01-01 00:00:00

abstract：:Frontotemporal dementias with parkinsonism linked to chromosome 17 (FTDP-17) are hereditary tauopathies affecting at least 50 known kindred worldwide. Most kindred present with severe behavioral or psychiatric manifestations progressing to dementia, while some kindred first manifest a parkinsonian-plus syndrome. Nine ...

journal_title：Neurobiology of aging

authors： Reed LA,Wszolek ZK,Hutton M

更新日期：2001-01-01 00:00:00

abstract：:The number of Alzheimer's disease sufferers shows an alarming increase throughout the world. Therefore elucidation of the pathogenic mechanisms leading to Alzheimer's disease and the design of effective treatment, preventive or curative, became imperative. In the last few years several groups have found evidence indic...

journal_title：Neurobiology of aging

authors： Nagy Z

更新日期：2000-11-01 00:00:00

abstract：:In the rhesus monkey primary visual cortex, there are bundles of vertically oriented myelinated axons, which mainly contain efferent fibers originating from pyramidal cells. At the level of layer 4Cbeta, the bundles are regularly arranged and the nerve fibers in them are closely packed. In order to determine if a sign...

journal_title：Neurobiology of aging

authors： Nielsen K,Peters A

更新日期：2000-09-01 00:00:00

abstract：:This paper describes regional brain energy metabolism, sensorimotor, and memory functions in mature (12 months) and old (24 months) C57BL/6 mice. Male mice were tested across a variety of sensorimotor procedures and in the Morris water maze before evaluating brain uptake of fluorodeoxyglucose (FDG) in the resting stat...

journal_title：Neurobiology of aging

authors： Uecker A,Gonzalez-Lima F,Cada A,Reiman EM

更新日期：2000-09-01 00:00:00

abstract：:Vascular disease and Alzheimer's disease are both common disorders, in particular among elderly subjects. Therefore, it can be expected that the joint occurrence of these two disorders is not a rare phenomenon. In recent years, evidence is increasing that the two may be more closely linked than just by chance. Epidemi...

journal_title：Neurobiology of aging

authors： Breteler MM

更新日期：2000-03-01 00:00:00

abstract：:This study investigates the age associated changes in hemorheological properties and cerebral blood flow. Partial correlations indicate that part of the age-dependent decrease in flow velocities can be attributed to a hemorheological decrement resulting in part from enhanced oxidative stress in the aged. A possible li...

journal_title：Neurobiology of aging

authors： Ajmani RS,Metter EJ,Jaykumar R,Ingram DK,Spangler EL,Abugo OO,Rifkind JM

更新日期：2000-03-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) are ubiquitously present within the perivascular basement membrane, and have been shown to be altered in patients with Alzheimer's Disease (AD). Although the HSPG agrin clearly orchestrates the differentiation of the neuromuscular junction, its role in the brain remains unclear. G...

journal_title：Neurobiology of aging

authors： Berzin TM,Zipser BD,Rafii MS,Kuo-Leblanc V,Yancopoulos GD,Glass DJ,Fallon JR,Stopa EG

更新日期：2000-03-01 00:00:00

abstract：:The midsagittal cross-sectional dimensions of the corpus callosum, the coronal cross-sectional area of the lateral ventricles at the level of the pons, and a three-dimensional estimate of intracranial volume were derived from magnetic resonance brain images obtained from 45 monozygotic and 40 dizygotic male twin pairs...

journal_title：Neurobiology of aging

authors： Pfefferbaum A,Sullivan EV,Swan GE,Carmelli D

更新日期：2000-01-01 00:00:00

abstract：:Aged rats exhibit an impaired ability to sustain long-term potentiation in dentate gyrus which correlates with a decrease in arachidonic acid concentration. Here we confirm the previous finding that dietary supplementation with arachidonic acid and its precursor, gamma-linolenic acid, reversed the impairment in LTP in...

journal_title：Neurobiology of aging

authors： McGahon BM,Murray CA,Horrobin DF,Lynch

更新日期：1999-11-01 00:00:00

abstract：:The genetic analysis of the yeast replicative life span has revealed the importance of metabolic control and resistance to stress. It has also illuminated the pivotal role in determining longevity that the RAS genes play by the maintenance of homeostasis. This role appears to be performed by the coordination of a vari...

journal_title：Neurobiology of aging

authors： Jazwinski SM

更新日期：1999-09-01 00:00:00

abstract：:Deletions of the mitochondrial DNA (mtDNA) have been shown to accumulate with age in a variety of species regardless of mean or maximal life span. This implies that such mutations are either a molecular biomarker of senescence or that they are more causally linked to senescence itself. One assay that can be used to de...

journal_title：Neurobiology of aging

authors： Melov S,Schneider JA,Coskun PE,Bennett DA,Wallace DC

更新日期：1999-09-01 00:00:00